Smoother, firmer skin.
Signals collagen and elastin production, improving skin texture and firmness.
PRESCRIPTION-GRADE
Medicine for your skin. Built around you.
Skin · Copper peptide
GHK-Cu Serum Rx
Prescription-strength skin longevity, made for you.
Your skin makes less GHK-Cu every year. We bring it back, at prescription strength. This copper peptide wakes up collagen and speeds the cellular renewal that slows with age. Firmer, smoother, more alive.
- Prescription-strength GHK-Cu, not an OTC concentration
- Prescribed for your skin specifically
- Compounded by a licensed U.S. pharmacy
- A clinician who stays to guide and adjust
Monthly
$99/mo
$99/mo
Quarterly Best deal
$237 every 3 mo · save $60
$79/mo
Split into payments with affirm Klarna
What to expect
Gradual, real change on a real timeline. Skin texture often begins to turn around week 4 — usually the first thing you feel before you see it. Fine lines soften and firmness builds through weeks 8–12, where the research measures its strongest numbers. A clinician stays on it with you, adjusting as your skin responds.
Ingredients
Active: GHK-Cu (copper tripeptide-1), prescription-strength, compounded for your skin.
Base: [Confirm full base & inactive ingredients from the formulation.]
All prescriptions require a consultation with a licensed provider, either asynchronously or synchronously. If the provider determines the medication isn't appropriate for you, you'll receive a full refund.
PRESCRIPTION-GRADE
Your skin will feel the difference.
Fewer fine lines.
Helps collagen rebuild faster than it breaks down, so wrinkles soften over time.
A more even, clearer tone.
Quiets inflammation and evens out skin, for a healthier look week after week.
A stronger skin barrier.
Supports your skin's natural repair, so it stays calmer, more resilient, and better hydrated.
THE RESEARCH
What 50 years of research on the GHK-Cu molecule shows.
70% vs 40%
more collagen production than retinoic acid, without the irritation
Histologic comparison — Abdulghani 1998
Figures describe published research on the GHK-Cu molecule, not results from Alfi's compounded formula. Compounded medications are not FDA-approved for safety, effectiveness, or quality. Individual results vary.
WHAT TO EXPECT
Visible results in weeks.
Weeks 1–3 · Getting started
Your skin adjusts
Your skin adjusts to a peptide it already recognizes. Most people notice nothing dramatic yet and that's normal. The work is starting underneath.
Week 4 · Texture turns
Texture turns
Skin texture begins to improve. The first thing most people feel before they see it.
Week 8 · Lines soften
Lines soften
Measurable change in wrinkle depth and volume in controlled trials. (Badenhorst 2016)
WEEK 12+ · PEAK RESULTS
Peak results
Firmness, clarity, and smoothness at their fullest. This is where the research measures its strongest numbers and where consistency pays off. (Badenhorst 2016)
There's no overnight version. Structural change is gradual by nature. That's exactly why a clinician stays on it with you, adjusting as your skin responds.
Start your assessment
THE SCIENCE
Your skin already knows GHK-Cu.
GHK-Cu is a peptide your body produces to repair itself. Over time, our bodies produce less of it, slowing down regeneration and making our skin thinner and less elastic.
By reintroducing GHK-Cu, you signal your skin cells to switch the repair pathways back on, and shift aging skin toward a younger, more resilient state.
Skin's repair signal restored with GHK-Cu
What it helps with
One molecule, many ways your skin uses it.
| Skin concern | How GHK-Cu helps |
|---|---|
| Fine lines & wrinkles | Stimulates new collagen to fill wrinkle volume; inhibits MMP collagen breakdown. |
| Skin firmness & laxity | Increases dermal density; stimulates elastin and collagen VI for structural support. |
| Texture & roughness | Remodels superficial collagen; improves barrier proteins for a smoother surface. |
| Redness & inflammation | Downregulates TNF-α and inflammatory cytokines; activates antioxidant enzymes. |
| Acne scarring | Accelerates tissue remodeling — the same wound-healing mechanism as surgical recovery. |
| Sun damage & photoaging | Rebuilds UV-degraded collagen; reduces MMP activity triggered by UV. |
| Post-procedure recovery | Accelerates tissue repair; reduces downtime after peels, microneedling, and laser. |
Describes mechanisms reported in published research on the GHK-Cu molecule.
How we compare
A repair cream can't do this. A doctor can.
| Alfi GHK-Cu | A typical repair cream | |
|---|---|---|
| Prescription-strength GHK-Cu | OTC concentrations only | |
| Reviewed and prescribed for your skin | One formula for everyone | |
| A personalized Alfi Protocol™ | — | |
| A clinician to answer questions | — | |
| Formula adjusted as your skin changes | — | |
| Compounded by a licensed U.S. pharmacy | — |
How to use
Simple, once a day.
01
Apply.
A thin layer to clean skin during your evening routine. Nighttime is when your skin's natural repair cycle peaks.
02
Let it absorb.
Give it a minute to sink in before anything else.
03
Be consistent.
Once daily for clinical-grade results. The results compound over weeks.
Directions shown are general guidance. Follow the directions your physician provides.
Who formulates it
The pharmacist behind your formula.
Dan DiStephano · Lead Pharmacist & Head of Formulation
Dan led pharmacy operations and R&D for top telehealth brands like Hims and 9amHealth, developing novel treatments. He's helped bring innovative products to market across multiple clinical categories.
How it works
From assessment to your formula, simply.
01
Share your health history.
Answer a few questions about your skin concerns and goals.
02
A physician reviews your answers.
Reviewed and prescribed for your skin, if applicable. Usually within a day.
03
Delivered, and adjusted over time.
Compounded by a licensed U.S. pharmacy, shipped discreetly, and refined as your skin responds — with a clinician on hand throughout.
GET STARTED
Start your skin protocol.
Monthly
Billed $99 each month · cancel anytime
$99/mo
Quarterly Best deal Save $60
20% off · charged $237 every 3 months · cancel anytime
$79/mo
$237 / 3 mo
Prescription-strength GHK-Cu creamPhysician review & your Alfi Protocol™Ongoing clinical supportFree, discreet shippingAdjust or cancel anytime
VERIFIED CUSTOMERS
What people are saying.
★★★★★
"My skin feels like mine again. It's subtle at first, then one morning you just notice it looks rested."
Verified Maya R. · 6 months in
★★★★★
"Having a doctor actually answer me and adjust things is the part I didn't know I needed."
Verified Daniel K. · 4 months in
More about Alfi
Skin is where it starts. Not where it ends.
Alfi treats from the inside out — real medicine, prescribed by clinicians, built into protocols made for your body. We believe health is about being your best self for the moments that matter: energy to stay out late-late, glowing during a chance encounter on the train, sharp for the entire four hour work meeting.
Clinician-first. Joyfully so.
Explore the program
FAQ
Good questions, answered.
Is this real medicine?
Yes. GHK-Cu is prescribed by a board-certified physician and compounded by a licensed U.S. pharmacy.
How is this different from a peptide serum I can buy?
Concentration, personalization, and a doctor. OTC serums are capped at cosmetic strengths and are one formula for everyone. Yours is prescribed for your skin and adjusted over time.
How long until I see results?
While individual experiences may vary, many users begin to notice improvements in skin hydration and texture shortly after application. For optimal results, use consistently as part of your daily skincare routine, with significant benefits typically observed after 4 to 12 weeks of regular use.
Does it irritate like retinol?
GHK-Cu is generally well tolerated; in one comparison it raised collagen more than retinoic acid without the irritation. Your clinician will guide your routine.
Is it safe?
GHK-Cu is your body's own peptide and well studied topically. Your provider will review your health assessment and determine if treatment is right for you.
Is insurance required?
Insurance isn't required, so there are no complicated insurance questions or health insurance plan considerations.